Yam dab tsi cuam tshuam rau kev ua tau zoo ntawm lub tshuab ntxhua khaub ncaws khov kho?

Kws Txhob khov kho lub tshuab ziab khaub ncaws ua si ua lub luag haujlwm tseem ceeb hauv kev tsim khoom thiab txuag ntau yam tshuaj kho mob, los ntawm cov tshuaj tiv thaiv cov tshuaj tua kab mob. Cov tshuab txawj ntse no, tshwj xeebLub tshuab ntxhua khaub ncaws khov loj, yog tsim los tshem tawm ya raws los ntawm cov tshuaj ntawm sublimation, ua tau zoo txuas lawv lub txee lub neej thiab tswj lawv lub potency. Txawm li cas los xij, kev ua haujlwm ntawm cov tshuab ziab khaub ncaws khov no tuaj yeem cuam tshuam los ntawm ntau cov khoom siv rau cov yam ntxwv tshwj xeeb ntawm cov khoom lag luam raug ua tiav. Nkag siab txog cov tuam txhab ua lag luam tsom rau lawv cov nqi ntawm Lyophilization, txo cov khoom lag luam zoo tshaj plaws ntawm lawv cov khoom khov-qhuav. Cov lus sau no rho tawm cov ntsiab lus tseem ceeb uas cuam tshuam rau cov chaw tsim khoom khov, muab cov haujlwm kom qhuav thiab ua tiav cov txheej txheem ntau dua.

 

Tus tsim qauv ntawm lub tshuab ntxhua khaub ncaws khov tshuab hluav taws xob cuam tshuam nws kev ua tau zoo. Niaj hnub khov lub tshuab ziab khaub ncaws ua kom muaj cov tshuab siab tshaj plaws uas txhim kho kev ua tau zoo thiab kev ntseeg tau. Lub peev xwm condenser, piv txwv li lub peev xwm tseem ceeb, ua lub luag haujlwm tseem ceeb hauv kev txiav txim siab ntau npaum li cas vapor lub tshuab ziab khaub ncaws khov ntau npaum li cas. Cov condenser loj tso cai rau kev txo qis dua vapor tshem tawm, txo lub sijhawm qhuav tag nrho. Ib yam li ntawd, cov hluav taws xob system tus qauv tsim cuam tshuam rau kev faib ua tshav kub sib faib thoob plaws cov khoom lag luam, cuam tshuam txog kev sib xws ntawm cov txheej txheem khov-kom qhuav. Lwm qhov kev tsim qauv tseem ceeb yog lub vijtsam txheem teeb tsa. Kev tsim kho cov txee kom muaj peev xwm ua kom cua sov kom sov thiab cov sublimation. Cov chaw sib nrug ntawm txee thiab lawv cov khoom siv tuaj yeem cuam tshuam cov nqi kub hloov, tus nqi hloov cua kub, qhov kawg muaj qhov khov-kom qhuav voj voog kom lub sijhawm ntev thiab cov khoom lag luam zoo. Tsis tas li ntawd, Chamber loj thiab cov duab ua rau muaj kev ua tau zoo tag nrho. Ib qho kev tsim qauv zoo ib yam li cov khoom siv kub thiab txias thiab txhawb cov khaub ncaws kom qhuav ntawm txhua yam khoom vials.

Kev siv tshuab thiab tswj kev tswj cov tshuab ntawm Niaj hnub nimno cov ntaub ntawv khov. Cov kab ke no tso cai rau kev tshuaj xyuas thiab kho kom haum ntawm cov tsis tseem ceeb xws li kub, thiab sijhawm. Kev tswj hwm cov txheej txheem ua tau zoo tuaj yeem hloov kho cov kev coj ua ntawm cov txheej txheem khov kho, ua kom zoo dua qub thiab ua kom muaj kev ua tau zoo nyob thoob plaws. Kev sib koom ua ke ntawm schanisticated shofors thiab cov ntaub ntawv ntawm cov ntaub ntawv tsom kwm ntau ntxiv txhim kho cov khoom muaj peev xwm los tswj hwm qhov kev ua tau zoo thoob plaws hauv Lyophilized.

Qhov xwm ntawm cov khoom lag luam khov kho kom khov-qhuav txaus cuam tshuam rau kev ua tau zoo ntawm cov txheej txheem. Cov tshuaj sib txawv uas nthuav qhia cov cwj pwm txawv thaum Lyophilization, uas tuaj yeem cuam tshuam lub sijhawm thiab ua tiav lub voj voog kom khov. Cov khoom pib noo noo, piv txwv li, ncaj qha rau kev siv hluav taws xob nrog lub zog thiab lub sijhawm uas yuav tsum tau ua tiav kom qhuav. Cov khoom lag luam uas muaj cov ntsiab lus noo noo ntau dua feem ntau yuav tsum tau ua cov sijhawm ua haujlwm ntev dua, muaj feem txo cov txiaj ntsig zoo.

Cov khoom lag luam thermal, suav nrog nws cov kev ua kom sov muaj peev xwm thiab thermal conductivity, cuam tshuam li cas nws teb rau qhov ntsuas kub hloov thaum qhuav. Cov ntaub ntawv nrog qis dua thermal conductivity yuav xav tau txuas ntxiv theem kom qhuav ua kom tiav sublimation ntawm cov dej khov. Ib yam li ntawd, cov khoom lag luam lub iav hloov cua kub (tg) yog qhov tseem ceeb tshaj plaws. Kev khiav hauj lwm saum toj no tus tuaj yeem ua rau vau rau ntawm cov qauv khoom lag luam, tsim nyog ua tib zoo tswj qhov kub thiab txias tswj thoob cov txheej txheem.

Cov qauv tsim ntawm cov khoom lag luam tshuaj kuj ua lub luag haujlwm tseem ceeb. Thov kom muaj kev zam rau kev ruaj ntseg lossis txhim kho cov yam ntxwv rov qab kho tuaj yeem cuam tshuam qhov cwj pwm khov-kom qhuav. Qee qhov kev ntxiv ntxiv tuaj yeem pab txhawb kev ziab kom qhuav los ntawm kev tsim cov qauv ntxeem tau, thaum lwm tus yuav tsim kev thaiv uas txo vapor tshem tawm. Nkag siab txog cov kev sib cuam tshuam no yog qhov tseem ceeb rau kev ua kom khov kho cov ntawv qhia kom qhuav thiab ua kom pom zoo ua haujlwm thiab ua kom pom zoo.

Vial puv ntim thiab thaj chaw thaj chaw-rau-ntim piv ntawm cov khoom kuj cuam tshuam kev txuag nyiaj. Cov khoom loj dua feem ntau yuav tsum tau lub sijhawm ziab ntev dua, thaum muaj qhov sib piv siab dua nyob rau hauv-rau-ntim sib piv tau tuaj yeem pab txhawb kev hloov pauv sai sai. Ua tib zoo xav txog cov xwm txheej tsim kev txhim kho thiab txheej txheem kev tsim qauv tuaj yeem ua rau muaj kev txhim kho tseem ceeb hauv qhov khov-kom qhuav.

 

Ib puag ncig uas ib tug loj portosutical khov kho tshuab ua haujlwm tuaj yeem cuam tshuam ntau yam cuam tshuam rau nws txoj kev ua tau zoo. Cov huab cua ambient kub thiab cov av noo hauv cov chaw tsim khoom tuaj yeem cuam tshuam cov khoom siv, tshwj xeeb yog thaum lub sijhawm ua kom haum. Cov av noo ntau dua tej zaum yuav nce cov thauj khoom ntawm cov condenser, muaj peev xwm txuas ntxiv ntawm lub sijhawm. Tswj ib puag ncig tswj ib puag ncig lub tshuab ziab khaub ncaws khov yog qhov tseem ceeb rau kev ua haujlwm zoo ib yam thiab ua haujlwm zoo.

Kev ua hauj lwm cov kev ua haujlwm kuj ua si lub luag haujlwm tseem ceeb hauv tshuab ziab khaub ncaws khov khov kho. Kev tu ncua thiab kev ntsuas kom haum ntawm cov cuab yeej ua kom pom kev ua tau zoo thiab tiv thaiv tsis tau zoo. Cov txheej txheem kom menyuam tsis muaj menyuam nruab nrab ntawm cov khoom siv tsis tseem ceeb xwb rau cov khoom lag luam zoo tab sis tseem yog rau kev tswj cov khoom siv ua tau zoo sijhawm. Cov kev tsis pom zoo cov ntaub ntawv no tuaj yeem ua kom txo qis kev hloov cua sov, ua haujlwm zoo, thiab lub sijhawm ntev dua.

Cov qauv thauj khoom ntawm vials nyob rau hauv lub tshuab ziab khaub ncaws khov yuav cuam tshuam airflow thiab faib cua sov. Tsis sib haum thauj khoom lossis cov khoom siv hluav taws xob ntau dua tuaj yeem tsim "kub me me" lossis thaj chaw tsis muaj qhov hloov cua sov, ua rau tsis sib xws ziab hla cov pob. Kev siv cov txheej txheem sib txuas thiab siv cov tais thauj khoom tsim rau kev ua kom zoo tshaj plaws tuaj yeem txhim kho efficiency.

Kev tswj hwm lub zog yog lwm qhov kev ua haujlwm tseem ceeb. Niaj hnub nimno cov ntaub ntawv khov kho no feem ntau teeb hluav taws xob txuag hluav taws xob xws li cov tshuab nqus cua sov thiab siv lub tshuab nqus tsev. Kev siv tau ntawm cov nta no, ua ke nrog cov qauv tsim kho kom zoo, tuaj yeem ua rau muaj zog txuag tau tsis muaj cov khoom lag luam zoo. Ib qho ntxiv, teem sijhawm khov-kom qhuav khiav kom tau txais txiaj ntsig zoo ntawm cov hluav taws xob ua haujlwm tuaj yeem txhim kho kev ua haujlwm los ntawm kev pom kev ua haujlwm.

 

 

Peb muab XXX, thov saib mus rau lub vev xaib hauv qab no kom cov ncauj lus kom ntxaws thiab cov ntaub ntawv cov ntaub ntawv.

Khoom:https://www.achievechn.com/freeer-dryer/pilot-freeze-dryer-html

 

Kev ua tau zoo ntawm cov kws tshuaj khov kho kom khov kho lub tshuab ziab khaub ncaws, tshwj xeeb yog chav tsev loj, yog pawg los ntawm cov txheej txheem sib cuam tshuam. Los ntawm cov khoom siv tsim thiab cov khoom lag luam rau cov kev mob ib puag ncig thiab kev ua haujlwm ua haujlwm, txhua lub ntsiab ua lub luag haujlwm tseem ceeb hauv kev txiav txim siab ntawm cov txheej txheem khov-kom qhuav. Los ntawm kev nkag siab thiab kev ua kom zoo dua cov xwm txheej no, cov haujlwm hauv lyophilized yuav ua rau cov khoom lag luam lyophilized, cov nqi qis dua, thiab cov nqi ntau lawm. Raws li thev naus laus zis txuas ntxiv mus ua ntej, kev sib koom ua ke ntawm cov ntse tswj, cov ntaub ntawv tshuaj xyuas, thiab kev tsim qauv tshiab cov yam ntxwv hauvLub tshuab ntxhua khaub ncaws khov lojCov lus cog tseg tau hais ntxiv thiab txhim kho kev ua tau zoo ntawm cov tshuaj tseem ceeb ntawm cov chaw tsim khoom.

 

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Patel, SM, DEEN, T., & Pikal, MJ (2010). Kev txiav txim siab ntawm qhov kawg taw tes ntawm thawj lub xub thawj ua kom qhuav cov txheej txheem tswj. AAPs kws muag tshuaj, 11 (1), 73-84.

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Franks, F. (1998). Nkoog-kom qhuav ntawm bioproducts: tso cov ntsiab cai rau hauv kev coj ua. Phau ntawv European ntawm cov kws tshuaj tebchaws thiab biophartutics, 45 (3), 221-229.