Los ntawm Lab mus rau kev tsim khoom, txo qis kev pheej hmoo nce ntxiv rau cov txiaj ntsig tsis sib haum

Txawm tias muaj cov cuab yeej siv niaj hnub no, cov chaw tsim tshuaj thiab tshuaj lom neeg tau ntsib ntau yam teeb meem thaum lawv txav lawv cov khoom los ntawm chav kuaj mus rau kev lag luam ntau lawm kab. Qhov no feem ntau ua rau degradation ntawm cov khoom zoo, nkim cov peev txheej, thiab raug nqi qeeb. Covlab- nplai cov tshuab ziab khaub ncaws(uas tuav lub<1 kg/hour) and the industrial-scale equipment processing (100+ kg/hour) have a wide gap between their capabilities and production capacity. Consequently, this makes it difficult to control quality during scale-up. That's why direct upscalling without intermediate testing leads to several problems, such as morphology, inconsistent moisture content, and thermal degradation of sensitive compounds.

Qhov no yog qhov uas tus tsav cov tshuab ziab khaub ncaws txuas qhov sib txawv los ntawm feem ntau muaj peev xwm ntawm 5-50 kg / teev. Hauv lwm lo lus, lawv tuaj yeem daws qhov teeb meem ntawm qhov ntsuas ntawm 500ml / teev hauv chav kuaj mus rau 100kg / teev ntawm qhov ntsuas ntau lawm. Tus tsav lub tshuab ziab khaub ncaws muab cov kev daws teeb meem nruab nrab yam tsis tau cia cov txheej txheem ua tsis zoo vim muaj kev hloov pauv loj. Nrog rau qhov blog no, peb yuav nkag siab tias yuav ua li cas tsav cov tshuab ziab khaub ncaws kom txo qis kev pheej hmoo los ntawm kev tshuaj xyuas cov kev cov nyom.

Nkag siab txog Pilot Spray Dryer Thiab Upscaling Challenges

Cov pilot tshuab ziab khaub ncawsmuab qhov zoo ntawm qhov ntim me me, qis suab nrov, qis zog noj, siab rov qab tus nqi, thiab kev ua haujlwm yooj yim. Lub tshuab tag nrho no siv tsawg dua ib square meter thiab tuaj yeem siv tau zoo hauv chav kuaj. Tsis tas li ntawd, lawv muaj ib qho - khawm pib- nce thiab xim LCD touchscreen rau kev ua haujlwm yooj yim. Tsis tas li ntawd, nws tuaj yeem siv manually rau kev sim vim li cas. Nws tsim cov tshuaj tsuag nrog cov kab uas hla ntawm 1-100 microns thiab ua tau zoo heev hauv kev ziab.

Tus kws tsav dav hlau- nplai tshuab ziab khaub ncaws muaj qhov kev tswj hwm qib siab, tso cai rau cov kws tshawb fawb los saib xyuas thiab kho txhua yam ntawm cov txheej txheem ziab. Kev nthuav qhia nws yog ib qho kev daws teeb meem zoo tshaj plaws los txuas rau chav kuaj rau kev lag luam scale - nce. Txawm hais tias koj tab tom ua haujlwm nrog cov cua sov- cov tshuaj rhiab heev los yog cov khoom lag luam muaj zog, lub tshuab ziab khaub ncaws no muaj kev ntseeg siab thiab qhov tseeb qhov tseem ceeb rau kev ua tiav qib- ua haujlwm.

Cov kev sib tw nce qib tau muab faib ua ob pawg:

1. Tus Sclae-Txoj kev nyuaj siab

Upscaling tshuaj tsuag kom qhuav yog qhov nyuaj tshaj qhov tsuas yog muab qhov ntev thiab qhov ntws. Tias yog vim li cas qhov kev hloov pauv coj qhov kev pheej hmoo loj, vim tias qhov kub thiab txias hloov pauv hloov pauv tsis sib xws. Atomization qauv kuj pib coj txawv txawv thaum lub nozzle siab, rotary atomizer ceev, los yog ob -fluid nozzle configuration yog scaled. Qhov no ua rau muaj kev cuam tshuam ncaj qha ntawm qhov pib qhov loj me me faib, qhov tseem ceeb ntawm qhov kev txiav txim siab kawg particle yam ntxwv.

 

Koj puas xav kawm Spray Dryer rau koj lub Lab?[Xa lus nug tam sim no]

2. Tej yam tshwm sim tsis ua hauj lwm

Qhov feem ntau tsis ua hauj lwm upscaling yog kev hloov pauv ntawm particle loj faib. Cov formulation uas ua rau 5-15 μm hais nyob rau hauv lub chaw soj nstuam yuav poob nthav tawm 15-40 μm hais vim qhov sib txawv ntawm atomization thiab ziab kinetics. Rau kev lag luam kws tshuaj, qhov kev hloov pauv no tuaj yeem ua rau tag nrho cov khoom tsim tawm. Moisture cov ntsiab lus variability tshwm sim los ntawm inconsistent drying thiab hloov pauv huab cua -rau-product ratio. Tib lub sijhawm, cov khoom lag luam tuaj yeem degrade yog tias cov ntaub ntawv rhiab heev muaj kev ntxhov siab thermal. Tsis tas li ntawd, lwm yam, xws li nce phab ntsa deposition, tuaj yeem txo 15-30% tawm los. Thiab thaum lub sij hawm scale-up, Reynolds tus naj npawb hauv cov tshuaj tsuag hloov los ntawm ib qho ntawm 10-100.

Technical Specification ntawm Pilot-Scale Spray Dryers

Ib lub rooj sawv cev ntawm cov yam ntxwv ntawm tus tsav lub tshuab ziab khaub ncaws uas ua rau nws yog qhov kev daws teeb meem zoo tshaj plaws rau kev txo cov kev pheej hmoo thaum lub sij hawm upscaling.

Specification	Cov ntaub ntawv ua haujlwm	Scale-Ua tau txiaj ntsig
evaporation peev	5L / H (dej sib npaug)	Muab cov nplai nruab nrab nruab nrab ntawm lub lab (<1L/H) and production (>50L / H) rau kev siv tau zoo
Feed Rate Range	50-5000 mL / h (kho tau)	Ntau yam ua rau kev tsim kho kev tsim kho los ntawm cov txheej txheem validation ntawm ib lub platform
Kev Tswj Kub Kub	40-350℃nrog PID tswj	± 1℃qhov tseeb kom ntseeg tau tias thermal keeb kwm rov ua dua cov txheej txheem tsim khoom thoob plaws ntau hom kev siv
Atomization Systems	Siab -ceev centrifugal (10,000-25,000 RPM) los yog ob-kua nozzle	Customizable Options match ntau lawm atomization tshuab rau particle morphology sib xws
Tswj interface	Advanced PLC nrog 10-nti touchscreen	Tiag -Kev saib xyuas lub sijhawm thiab cov ntaub ntawv kaw lus txhawb QbD thiab cov ntaub ntawv tswj hwm
Khoom siv hauv tsev	304 stainless hlau nrog polished xaiv	GMP- cov ntaub ntawv ua raws li cov khoom lag luam kom huv si thiab ua kom muaj kev nyab xeeb
Kev xav tau lub zog	380V / 50Hz, 15KW tag nrho	Kev siv hluav taws xob nruab nrab tsim nyog rau R & D cov chaw tsis muaj hluav taws xob tshwj xeeb
Cov cuab yeej Footprint	1500 × 1200 × 2500 hli (L × W × H)	Compact tsim haum rau cov qauv kuaj qhov chaw, txo cov peev txheej
Kev ruaj ntseg Systems	Tsis siv neeg kaw, dhau- tswj qhov kub thiab txias, tawg- pov thawj xaiv	Tiv thaiv cov ntaub ntawv muaj txiaj ntsig thiab ua kom muaj kev nyab xeeb ntawm kev ntsuas cov kuab tshuaj thiab cov khoom tawg

 

Koj puas xav kawm Spray Dryer rau koj lub Lab?[Nug ib tug engineer tam sim no]

Kev xav zaum kawg!

Raws li tau hais los saum toj no, tus tsav cov tshuab ziab khaub ncaws yog cov cuab yeej tseem ceeb rau kev txo lossis txawm tias tshem tawm kev pheej hmoo thaum nce hauv koj ib puag ncig. Qhov no ua rau koj qhov kev nce qib nce mus tau yooj yim thiab poob -dawb los ntawm kev txuas qhov sib txawv ntawm chav kuaj thiab cov khoom lag luam xav tau. Qhov kev lees paub txuj ci tseem hais txog nws cov txiaj ntsig los ntawm kev hais txog qhov kev pheej hmoo uas nws txo qis xws li cov khoom siv pov tseg, kev ua tsis tau zoo, thiab ua kom lub sijhawm nrawm dua - mus rau - kev ua lag luam. Cov tuam txhab uas tab tom nrhiav rau cov cuab yeej txhawb nqa uas yuav txo qis qhov kev pheej hmoo xav tau Achieve Chem's pilot spray dryers. Nws yog tsim nrog precision engineering thiab scalable tsim, muab evaporation muaj peev xwm ntawm 5-50 kg / teev nrog advanced tswj systems.

Cov lus nug nquag

Qus 1.Dab tsi yog qhov muaj peev xwm zoo tshaj plaws rau tus tsav lub tshuab ziab khaub ncaws?

Ans:Qhov zoo tshaj plaws muaj peev xwm sib txawv ntawm 5- 50 kg / teev ntawm dej evaporation mus rau 10-100 kg / teev pub tus nqi, nyob ntawm seb cov ntsiab lus khoom. Qhov zoo tshaj plaws ntau yam rau kev ntsuam xyuas muaj txiaj ntsig.

 

Qus 2.Yuav tsum muaj pes tsawg tus tsav tsheb ua ntej scaling rau ntau lawm?

Ans:Feem ntau, 3-5 batch yog txaus rau kev siv tau ntawm cov txheej txheem tseem ceeb thiab hloov pauv los ntawm kev sim mus rau ntau lawm. Qhov no txuag 10-20 cov khoom tsim tawm uas yuav xav tau thaum tsis muaj cov ntaub ntawv ntsuas ntsuas.

 

Qus 3.Tus kws tsav dav hlau Cov tshuab ziab khaub ncaws puas tuaj yeem tswj cov cua sov- cov tshuaj rhiab heev?

Ans:Cov tshuab ziab khaub ncaws niaj hnub no muab kev tswj qhov kub thiab txias (1-2 degree), lub sijhawm nyob luv luv (5-30 vib nas this), thiab muaj peev xwm ua tsis taus pa rau cov khoom siv oxygen. Cov cuab yeej zoo tshaj plaws rau biologics, probiotics, thiab thermolanile APIs.

 

Qus 4.Dab tsi yog qhov ntsuas ntsuas - nce piv los ntawm kev tsav mus rau kev tsim khoom?

Ans:Qhov ntsuas ntsuas ib txwm- nce qhov sib piv ntawm 1:10 txog 1:20 nyob rau hauv cov nqe lus ntawm cov peev txheej. Qhov tseem ceeb yog tswj cov txheej txheem zoo sib xws (lub zog tawm tswv yim ib kg ntawm cov khoom) es tsis yog qhov yooj yim geometric scaling.