5L iav reactor

Tus5L iav reactoryog yooj yim siv, zoo nkauj nyob rau hauv tsos thiab yig. nws yog ib qho khoom siv zoo tshaj plaws rau cov khoom siv tshiab ntawm cov khoom tshiab .

Lub ntsuas yog tag nrho cov txheej txheem, thiab cov tshuaj reactor tuaj yeem nqus tau lub siab ua kom haum, thiab cov khoom siv ua kua los yog nqus tau los ntawm cov siab tsis zoo.

Peb muab5L iav reactor, thov saib mus rau lub vev xaib nram qab no kom cov ncauj lus qhia ntxaws ntxaws thiab cov ntaub ntawv khoom lag luam .

Khoom:https: // www . . com / tshuaj-tshuaj / raise {}. HTML

 Nyem kom tau txais tag nrho cov nqi teev

 

Muaj peev xwm:Nws yog qhov haum rau cov ntsuas kev lag luam me me . Lub peev xwm yuav tsum tau raug xaiv raws li kev sim tshwj xeeb.

● Khoom siv:Ua los ntawm high borosilicate iav, uas muaj zoo corrosion tsis kam thiab tshuaj lom neeg cov kev daws teeb meem thiab cov kuab tshuaj muaj zog.

● Cov qauv:Tsim ntawm lub nkoj tiv thaiv, ib lub hau, ib qho khoom siv kub, ib lub chaw nres tsheb tawm ntawm lawv, ntawm cov khoom sib txuas thiab kev nyab xeeb ntawm cov txheej txheem tshuaj tiv thaiv .

Cua sov thiab cua txias:Nruab nrog cua sov thiab txias txias, uas tuaj yeem tswj tau los ntawm lub tsho rau sab nrauv kom muaj kev ruaj khov ntawm cov tshuaj tiv thaiv kub.

Ntaus Dirring:Txhawm rau txhawb nqa cov khoom siv hluav taws xob tag nrho thiab cov khoom siv sib txawv ntawm cov ntaub ntawv tiv thaiv, lub khob stirrer yog feem ntau muaj cov khoom sib nqus, uas tuaj yeem paub txog cov ntaub ntawv thiab ncua ntawm cov ntaub ntawv.

● Tswj system:Nruab nrog kev tswj qhov kub

Kev Nyab Xeeb:Muaj kev nyab xeeb zoo, thiab lub hau yog ntim cov khoom muaj kev ntseeg siab tseem yuav pab txo cov khoom qias tuaj ntawm cov txheej txheem cov tshuaj tiv thaiv {}}

● Teeb thiab Calibration

Leveling: kom cov reactor tau muab tso rau ntawm qhov ruaj khov, qib deg .

Kev ntsuas dej: Cov pa tawm ntawm lub nkoj nrog cov pa nitrogen (1-2 bar) thiab kos rau txau uas siv xab npum {}}

Kev ntsuas hluav taws xob: Pom tseeb cov sensors thiab siab gauges tawm tsam cov ntawv pov thawj .

● Kev Tawm Tsam Kev Ua Haujlwm

Kev them cov lus hais: Ntxiv cov khib nyiab ua ntej, ua raws li cov hmoov av kom txo cov plua plav plua plav {}}

Stirringing offondization: Pib ntawm qis ceev (100 RPM) thiab maj mam nce kom tsis txhob splashing .

Cov neeg kub kub hnyiab tau: Rau cov kev tawm tsam kub, txwv cov nqi ntsuas kom tsawg dua lossis sib npaug rau 5℃/ min.

● Kev kuaj thiab tsom xam

Cov txheej txheem Aseptic: Siv cov koob txhaj tshuaj tsis huv thiab koob rau bioractions .

Cov Sensors: Tso Cai Physing, los yog lossis ua (Desolved oxygen) probes rau kev tshuaj xyuas lub sijhawm tiag tiag.

● Kaw thiab tu

Quenching: sai sai txias lub reactor yog tias kev tswj tsis tau tshwm sim .

Txhuav: Siv lub tshuab nqus tsev kom tshem tawm cov kuab tshuaj uas zoo .

Kev ntxuav tu: Ntxuav nrog dej deesized, ua raws li acetone lossis ethanol {}}}}} {.

ITOCAN siv rau ion pauv kev hloov pauv, uas yog ib pawg tshuaj tiv thaiv kev kho mob hauv hiav txwv thiab kev sib cais thiab catalyy.
Hauv Ion Hloov cov tshuaj tiv thaiv, cov tshuaj tiv thaiv thiab cov khoom sib pauv theem muaj cov khoom siv tshwj xeeb, thiab tuaj yeem tso cov tshuaj lom neeg tshwj xeeb lossis tso tawm cov ions ions.

Tsis ntev los no kev txhim kho thiab thev naus laus zis cov tshuaj tua hluav taws xob tau tsom rau kev txhim kho kev nyab xeeb, thiab hloov kho cov kev siv tshuab, thiab hauv qab no yog qhov tseem ceeb tsim:

● Advessenial kub tswj cov tshuab

Niaj hnub 5L cov iav reactors tam sim no sib xyaw ua ke nrog kev tswj hwm kub siab (E6}}}} (e {{{{8} g .}}} Ib cov qauv kev txhawb nqa lub cev kub thiab txias, tso cai rau cov khoom siv daws teeb meem.

● Kev siv tshuab thiab plc kev sib xyaw ua ke

Programmable cov kev tswj hwm logic (PLCS) tau koom ua ke rau hauv 5}} Qhov no ua rau muaj kev tswj hwm ntau yam, nrog rau cov ntaub ntawv ntau, thiab cov ntaub ntawv kub thiab cov ntaub ntawv tiag tiag Kev nkag mus . Cov rechar kuj tseem txhawb nqa cov chaw taws teeb lossis cov neeg ua haujlwm huab los kho cov tsis tawm ntawm qhov chaw {}

● Kev txhim kho kev nyab xeeb nta

Kev Nyab Xeeb Kev Nyab Xeeb suav nrog cov khoom siv tawg-pov thawj, thiab cov tshuaj tiv thaiv kev phom sij (E6 3}} borosilicate iav txo qhov kev pheej hmoo ntawm txim taws ua rau muaj kev tiv thaiv ib puag ncig hauv cov pa hluav taws kub.

● High-shear sib xyaw thiab homogenization

Txhawm rau txhim kho emulsion stability thiab particle loj tswj (e {}} kev sib cais ua tiav thiab muaj kev sib cais, tseem ceeb rau tshuaj thiab cov tshuaj pleev ib ce cov qauv . Cov qauv kuj tseem muaj kev sib nqus txuas rau co lauj kaub-pov thawj, High-Torque Stirring {}}

Matau thiab cov qauv tsim qauv

Cov chaw tsim khoom tam sim no muaj cov neeg tsim khoom me me 5 tus pas dej sib txawv pilot cog . Cov reine} Qee cov reactors tseem tau tshaj multtreactor arrays, ua kom cov synthector rau qib siab dhau los ... {10}

► Cov Ntaub Ntawv Kev Kawm 1: Kev Tsim Kho Tshuaj - Txhim kho cov lus qhia API

Lub hom phiaj

Ib lub tuam txhab nruab nrab ntawm cov chaw tsim hluav taws xob taw qhia txog cov synthesis ntawm ib lub hom phiaj kev sim siab (API

Kev sib tw

Yield variability: flask-raws li kev coj ua tau zoo heev purity (75-85%) vim qhov tsis zoo tov thiab kub grates .

Kev txhawj xeeb txog kev nyab xeeb: Cov tshuaj tiv thaiv cuam tshuam nrog exothermic grignard reagent ntxiv, pheej hmoo thermal khiav khiav tawm {}}

Scalability: Kev hloov mus los ntawm 250 ML flasks mus rau 5L reactor yuav tsum tau kho kom meej tswj ntawm Stoichiometry thiab chaw nyob lub sijhawm .

Lus teb

Reactor Teeb: Ib lub Jacketed 5L iav Reactor nrog lub tshuab ua haujlwm stirrer, Refux Condenser, thiab Nitrogen Inlet tau siv .

Kev tswj qhov kub thiab txias: ib qho chiller chiller tswj cov tshuaj tiv thaiv ntawm -10℃(tseem ceeb rau grignard kev ruaj khov) .

Ib qho ntxiv cov txheej txheem: Lub grignard reagent tau ntxiv dropwise ntawm ib lub koob txhaj tshuaj tshaj plaws ntawm ib teev ntau dua 2 teev los tswj cov exothermicity {}}

Kev Saib Xyuas Kev Tswj Xyuas: HPLC cov qauv tau rho tawm ib teev teev rau kev ua raws li impurity formation.

Qho kawg

Bas Edjement: tiav 92% tawm los (vs . 82% nruab nrab hauv flasks) nrog 99 {30% purity.

Kev Nyab Xeeb: Tsis muaj thermal khiav xwm txheej, ua tsaug rau maj mam ntxiv cov nqi thiab txuag cua txias .

Lub Sij Hawm efficiency: Cov neeg xav txog lub sijhawm ntawm 16 teev (lub caij nyoog (ntxeev) mus rau 10 teev (reactor).

Cov tshooj lus kawm

Precia rov xaiv qhov kub: txawm tias muaj kev sib txawv me me (e {{}}}} -10 degree) ob npaug {}}

Ntxiv mus ntxiv rau kev txhim kho: Cov twj tso kua mis tau zoo dua ntawm kev tuav txoj kev.

Nplai-nce tau siv tau: Pilot-teev cov ntaub ntawv ua ke nrog Flask ua ntej, ua rau cov khoom siv hloov mus rau 50L reactor {}

► Kev Kawm Kev Kawm 2: Polymer Chemistry - synthesizing biodegradable nanoparticles

Lub hom phiaj

Cov ntaub ntawv ntaub ntawv tshawb fawb nrhiav txhim kho biodegradable poly (plga} Qhov kev sib tw yog los tswj cov palchle loj (PDI <2}} 2) hauv 5L reactor.

Kev sib tw

Agglomeration: nanoparticts tended rau pawg, yielding loj, tsis xwm yeem, {}}

Kev xaiv cov kev xaiv: dichloromethane (DCM) tau zoo tab sis yaj nrawm dhau, cuam tshuam emulsion ruaj khov .

Stirring efficiency: Cov tshuaj nkag tsis tau zoo ua tsis tau zoo kom tswj cov dej num tsis muaj nqis hauv organic theem .

Lus teb

Reactor hloov kho:

Ntsia lub siab-shear rotor-stator homogenizer kom tsoo cov mob o6.

Siv lub thoob coaxial ob lub tsho rau qhov ntsuas kub kom meej (25℃± 0 . 5 degree).

Cov kuab tshuaj: hloov DCM nrog kev sib xyaw ntawm ethyl acetate thiab acetone kom qeeb evaporation .

Surfactant Optimization: Ntxiv 1% w / v poly (Vinyl Cawv) (PVSE) kom ruaj khov .

Qho kawg

Qhov loj me me: tiav 85 ± 12 nm nrog PDI=0.15.

Morphology: tem imaging paub zoo kheej, tsis-aggregated nanoparticles .

Scalability: 5L cov txheej txheem tsim 400 g ntawm nanoparticles ib pob, txaus rau cov neeg tshawb nrhiav tsiaj .

Cov tshooj lus kawm

Homogenization tus yuam sij: high-shear sib xyaw txo qis batch-rau-batch hloov pauv los ntawm 60% .

Cov kuab tshuaj muaj zog: qeeb-evervorating cov kuab tshuaj kom tswj emulsion emulsion rau {}} feeb.

Surfactant Ntsuam Xyuas: PVA Outperformed Tween 80 hauv kev tiv thaiv kev tiv thaiv agregation.

Cov cuab yeej 5l reassor tseem yog qhov kev tshawb fawb tseem ceeb thiab kev hloov kho hauv kev lag luam, nce qib siab, thiab muaj kev sib tw hauv cov ntaub ntawv tshawb fawb thiab kev ua haujlwm hauv cov cuab yeej science thiab digital thev naus laus zis tau nthuav dav nws lub peev xwm . zoo li kev lag luam ua ntej ua tau zoo, kev nyab xeeb, ua yeeb yam hauv 5 lub luag haujlwm hauv cov txheej txheem ntawm cov txheej txheem ntawm cov kev siv tshuaj lom neeg.

Cim npe nrov: 5L Cov iav Reactor, Tuam Tshoj 5L Cov Ntaus Cov Tshuaj Tiv Thaiv, Chaw muag khoom, Hoobkas